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Overview of 4-Acetoxy-N,N-dimethyltryptamine (4-AcO-DMT)

4-AcO-DMT, also known as O-acetylpsilocin or psilacetin, is a psychedelic compound belonging to the tryptamine family. It is chemically related to psilocybin and psilocin, and serves as a synthetic derivative of psilocin (4-HO-DMT), with its hydroxyl group acetylated. The structure of 4-AcO-DMT is analogous to psilocybin (4-PO-DMT) in which the phosphate ester has been replaced with an acetate ester.

Chemical Properties and Action

4-AcO-DMT functions as a prodrug for psilocin, meaning it converts into psilocin within the body. When ingested, it acts as a non-selective serotonin receptor agonist, notably activating the 5-HT2A receptor. The hallucinogenic effects experienced with 4-AcO-DMT are primarily attributed to this receptor activation, although other serotonin receptors also play a role. Users often report that the effects are akin to those of psilocybin and psilocybin mushrooms, with the distinction that 4-AcO-DMT tends to produce fewer side effects, such as nausea and body load. Additionally, it has a faster onset and shorter duration of effects compared to psilocybin. Research suggests that 4-AcO-DMT is moderate in potency by weight, being less potent than psilocybin in animal studies when administered in equimolar doses.

Historical Background

The compound was first described in a patent by Albert Hofmann in 1963. A more refined chemical synthesis was developed by David E. Nichols and his colleagues in 1999. Nichols endorsed 4-AcO-DMT as a more economical and manageable alternative to psilocybin for scientific research, largely due to psilocybin's classification as a controlled substance and less accessible synthesis process. Its emergence as a designer drug in Europe was noted in 2009, and throughout the 2010s, it gained popularity as a recreational drug, becoming one of the most utilized novel tryptamines.

Recent Developments

In the 2020s, 4-AcO-DMT has increasingly appeared in the form of mushroom edibles across the United States, presenting itself as an alternative to psilocybin. These edibles may contain 4-AcO-DMT along with other compounds, including constituents of the Amanita muscaria mushroom or non-mushroom substances. Such variations have raised concerns about safety, with incidents of poisoning and fatalities linked to contaminated products.

Legal Status

Currently, 4-AcO-DMT is not classified as a controlled substance under U.S. law or international drug schedules, including the United Nations 1971 Convention on Psychotropic Substances. This legal status may render it more accessible for research purposes compared to psilocybin.

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How to Purchase 4-AcO-DMT (Freebase) in 2026

You can acquire 4-AcO-DMT (Freebase) along with other research chemicals right here at REAL-CHEMS. All of our products are rigorously tested by third-party laboratories. If you would like to view the HNMR results for 4-AcO-DMT (Freebase) or any other chemical, feel free to reach out to us.

Responsible Research Practices with 4-AcO-DMT (Freebase)

It is crucial to engage in responsible research practices. Make sure to read and educate yourself thoroughly before beginning any research with a chemical. The Psychonaut Wiki offers valuable resources and insights on 4-AcO-DMT (Freebase). Always ensure you have a solid understanding before conducting research with any chemical.

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4-AcO-DMT (Freebase) and all other items are intended solely for research purposes and are not meant for human consumption.

Keep 4-AcO-DMT (Freebase) in a cool, dry environment, protected from direct sunlight.

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4-AcO-DMT (Freebase) stock last updated at: March 2026