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What is Desmethylprodine (MPPP)

Desmethylprodine or 1-methyl-4-phenyl-4-propionoxypiperidine (MPPP, Ro 2-0718) is an opioid analgesic drug developed in the 1940s by researchers at Hoffmann-La Roche. It is an analog of pethidine (meperidine). Chemically, it is a reversed ester of pethidine which has about 70% of the potency of morphine. Unlike its derivative prodine, it was not reported to exhibit optical isomerism. It was reported to have 30 times the activity of pethidine and a greater analgesic effect than morphine in rats, and it was demonstrated to cause central nervous system stimulation in mice.

History of Desmethylprodine (MPPP)

Desmethylprodine was first synthesized in 1947 at Hoffman-LaRoche Laboratories by Albert Ziering and John Lee. They found that it produced effects similar to morphine when administered to rats. Ziering had been searching for synthetic painkillers that were less addictive than morphine. The new drug was a slight variant of pethidine. This research produced the analgesic alphaprodine (Nisentil, Prisilidine), a very closely related compound.

How to Purchase Desmethylprodine (MPPP) Powder in 2026

You can acquire Desmethylprodine along with other research chemicals right here at REAL-CHEMS. All of our products are rigorously tested by third-party laboratories. If you would like to view the HNMR results for Desmethylprodine (MPPP) Powder or any other chemical, feel free to reach out to us.

Responsible Research Practices with Desmethylprodine

It is crucial to engage in responsible research practices. Make sure to read and educate yourself thoroughly before beginning any research with a chemical. The Psychonaut Wiki offers valuable resources and insights on Desmethylprodine (MPPP) Powder. Always ensure you have a solid understanding before conducting research with any chemical.

Desmethylprodine and all other items are intended solely for research purposes and are not meant for human consumption.

Keep Desmethylprodine (MPPP) Powder in a cool, dry environment, protected from direct sunlight.

Desmethylprodine stock last updated at: March 2026